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. 2016 Oct 13;6:35326. doi: 10.1038/srep35326

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Copyright © 2016, The Author(s)

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The indicated residues (purple) of HLA-A2 were mutated individually or in combination and their effect on the binding energy, relative to WT HLA-A2 (ΔΔG), determined by SPR. Calculated values for the double mutants are the sum of ΔΔG values measured for the single mutant. Data for single mutants is from Tables S1–S4. Data for double mutants represents the mean of at least three determinations with a SD less that 0.06 kcal.mol⁻¹.