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. 2016 Oct 13;6:35202. doi: 10.1038/srep35202

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Nuclear YAP1 was detected in the limbal and corneal basal cells. DAPI was used for nuclear counterstaining. The arrows and arrowheads indicate the same position in the corneal and limbal epithelia, respectively. (B,C) Mosaic GFP expression at cornea basal layer of Krt12^R/R/TC/Rosa26^F/GFP (K12/GFP) mouse at 7 week old (B), but absent in the age matched Krt12^R/R/TC/Rosa26^F/GFP/Yap1^fl/fl (K12/GFP-Yap1KO) mouse (C). The images were taken immediately after 7 days of Dox treatment. (D,E) Live images taken from a Krt12^R/R/TC/Rosa26^F/GFP (K12/GFP) mouse (D) and Krt12^R/R/TC/Rosa26^F/GFP/Yap1^fl/fl (K12/GFP-Yap1KO) mouse (E) at the different time points after Dox withdrawal. The mice at five weeks of age were fed with Dox diet for 7 days, then followed by regular chow without Dox for indicated days. Scale bars = 35 μm in (A), 50 μm in (B,C), 2 mm in (D,E). The images shown are representatives from 5 eyes examined.