Table 1.

Venom Insulins are Widely But Not Ubiquitously Expressed in Cone Snails.

Species	Subgenus	Prey	Venom insulin	Methodology
C. geographus	Gastridium	Fish	+	Illumina, 454 (Hu et al. 2012)
C. tulipa	Gastridium	Fish	+	RT-PCR (Safavi-Hemami et al. 2015)
C. bullatus	Textilia	Fish	−	Illumina
C. striatus	Pionoconus	Fish	−	Illumina
C. victoriae	Cylinder	Snail	+	454 (Robinson et al. 2014, 2015)
C. textile	Cylinder	Snail	+	Illumina
C. marmoreus	Conus	Snail	+	Illumina
C. bandanus	Conus	Snail	+	RT-PCR
C. distans	Fraterconus	Worm	−	Illumina
C. planorbis	Strategoconus	Worm	+	Illumina
C. generalis	Strategoconus	Worm	−	Illumina
C. varius	Strategoconus	Worm	+	Illumina
C. tribblei	Splinoconus	Worm	+	Illumina
C. floridulus	Lividoconus	Worm	+	RT-PCR (Safavi-Hemami et al. 2015)
C. quercinus	Lividoconus	Worm	+	RT-PCR (Safavi-Hemami et al. 2015)
C. andremenezi	Turriconus	Worm	−	Illumina
C. praecellens	Turriconus	Worm	−	Illumina
C. tessulatus	Tesseliconus	Worm	+	Illumina
C. eburneus	Tesseliconus	Worm	+	Illumina
C. pulicarius	Puncticulis	Worm	+	Illumina
C. virgo	Virgiconus	Worm	+	Illumina

Note.—Conventional signaling insulins were retrieved from all five species in which we looked for them (Conus geographus, C. striatus, C. bullatus, C. bandanus and C. virgo) and have very similar amino-acid sequences.