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. 2016 Oct 13;6:35320. doi: 10.1038/srep35320

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Copyright © 2016, The Author(s)

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(A) Reversal by SAR218645 of an MK-801-induced deficit of episodic memory in an object recognition task in mice. Each bar represents the average (+SEM) time spent exploring a novel or a familiar object. The delay between the acquisition and the recall session was 60 min. Post hoc analyses following a two-way ANOVA: **P < 0.01 and ***P < 0.001 novel vs familiar object at the considered treatment condition. N = 8 to10 mice per group. (B,C) Effect of a single administration of SAR218645 (0.1 mg/kg, po, SAR) on (B) spontaneous alternation and (C) number of arm entries in the Ymaze test in wild-type (WT) and NMDA Nr1^neo−/− mice. Bars represent Mean + S.E.M. **P < 0.01 (vs. control), ^$P < 0.05 (vs. chance level) and ^#P < 0.001 (vs. WT). N = 10–11 mice per group.