Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 13;6:35320. doi: 10.1038/srep35320

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A,C) Concentration-response curves for glutamate in the absence or in the presence of increasing concentrations of SAR218645 (SAR) in cell lines expressing rat mGluR2 and human mGluR2, respectively. (B) Concentration-response curve of SAR218645 in the presence of a submaximal concentration (EC₁₀) of glutamate (Glu) in HEK293 cells stably expressing rat mGluR2 on Ca²⁺ mobilization. Antagonism of this effect by the mGluR2/3 receptor antagonist, LY341495. The fluorescence responses were normalized as a percentage of the maximal response to glutamate (10 or 100 μM) and represent the means ± S.E.M.