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Concentration-dependent intracellular calcium increases stimulated by the agonist L-glutamate in the presence and in the absence of 10 μM SAR218645 was measured in cells expressing mGluRl, mGluR2, mGluR3, mGluR6, mGluR7 and mGluR8. Concentration-dependent intracellular calcium increases stimulated by SAR218645 in the presence or in the absence of EC20 of agonist L-glutamate was measured in cells expressing mGluR2 and mGluR3.
