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. 2016 Oct 13;6:35320. doi: 10.1038/srep35320

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Copyright © 2016, The Author(s)

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(A) SAR218645 potentiation of glutamate (Glu) inhibition on 1 μM forskolin-stimulated cAMP production in HEK293 cells expressing human mGluR2. The assay was performed in the presence of an EC₂₀ concentration of glutamate. Data represent the mean ± S.E.M. (B,C) [³⁵S]GTPγS binding to mouse cortex. (B) Concentration-effect curve for SAR218645 on the binding of [³⁵S]GTPγS in the presence or in the absence of glutamate (Glu). Antagonism of this effect by the mGluR2/3 receptor antagonist, LY341495. (C) Stimulation of [³⁵S]GTPγS binding produced by glutamate (Glu) in the absence or in the presence of SAR218645. Data are expressed as percentage of the maximal response to glutamate (100 μM) and are mean ± S.E.M.