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(A) Dose-response; (B) antagonism of the effects of SAR218645 given orally by the mGluR2/3 antagonist, LY341495. Data represent Mean + S.E.M. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. LY404039 (Wilcoxon two-tailed comparison vs. LY404039). N = 10 per group.
