Table 1. Pharmacokinetic parameters of SAR218645 following oral administration in mice.
| Dose (mg/kg) | Tissue | Cmax (ng/mL or ng/g) | tmax (h) | AUC(0-tlast) (hr.ng/mL or hr. hr.ng/g) | tlast (h) | AUC(0-inf) (hr.ng/mL or hr. hr.ng/g) | T1/2 (h) | Brain/plasma ratio (AUC0-inf) |
|---|---|---|---|---|---|---|---|---|
| 1 | Plasma | 131 | 0, 5 | 230 | 8 | 230 | 1, 5 | 0, 41 |
| Brain | 32 | 1, 0 | 91 | 8 | 94 | 1, 5 | ||
| 3 | Plasma | 434 | 0, 25 | 540 | 8 | 540 | 0, 99 | 0, 52 |
| Brain | 103 | 1, 0 | 280 | 8 | 280 | 1, 0 | ||
| 10 | Plasma | 1080 | 0, 5 | 2300 | 8 | 2400 | 1, 7 | 0, 42 |
| Brain | 339 | 1, 0 | 960 | 8 | 1000 | 1, 6 |
AUC(0-tlast), area under the time-concentration curve (measured between 0 and last sampling time, tlast); AUC(0-inf), extrapolation of AUC to infinity; Cmax, maximal concentration; T1/2, terminal half-life; tmax, amount of time that the drug is present at the maximum concentration in the tissue.