Table 3. Effects of SAR218645, haloperidol and the combination of SAR218645 and haloperidol in the catalepsy test in rats.
Treatment | Dose (mg/kg, po) | Time (s) |
---|---|---|
Vehicle | 14, 20 ± 4 | |
Haloperidol | 1 | 386, 2 ± 56, 08** |
SAR218645 | 30 | 20 ± 5, 5 |
SAR218645+haloperidol | 3 + 1 | 444, 6 ± 28, 3** |
SAR218645+haloperidol | 30 + 1 | 402, 8 ± 49, 95** |
Data represent amount of time each rat spent with at least one forepaw on the bar and are expressed as mean ± S.E.M. **P < 0.01 (Dunnett’s post hoc analysis). N = 10.