Table 1.
Summary of the GWAS data sets and results
| Quantitative trait | Relevant complex disease | GWAS-sample size | GWAS-number of SNPs | GWAS-significant SNPs | GWAS-significant locus |
|---|---|---|---|---|---|
| SBP | CVD | 406 | 396 968 | – | – |
| DBP | CVD | 406 | 396 968 | – | – |
| HDL | CVD | 516 | 387 558 | – | – |
| LDL | CVD | 499 | 387 345 | – | – |
| Triglycerides | CVD | 517 | 387 374 | rs6589677, rs500254, rs11217655, rs11217695 | 11q23.3 |
| Total cholesterol/HDL | CVD | 516 | 387 558 | – | – |
| Monocyte count | CVD | 653 | 390 542 | – | – |
| LAVI | CVD | 318 | 393 258 | – | – |
| LVMI | CVD | 320 | 393 024 | – | – |
| CIMT | CVD | 263 | 391 119 | – | – |
| FeNO | Asthma | 452 | 396 731 | – | – |
| FEV1 | Asthma | 697 | 391 522 | – | – |
| FEV1/FVC | Asthma | 700 | 392 576 | – | – |
| BRI | Asthma | 571 | 393 137 | – | – |
| Total serum IgE | Asthma | 788 | 390 188 | – | – |
| Lymphocyte count | Asthma | 654 | 390 392 | – | – |
| Eosinophil count | Asthma | 650 | 391 004 | – | – |
| Neutrophil count | Asthma | 653 | 390 560 | rs12634993 | 3p12.3 |
| YKL-40 | Asthma | 715 | 391 032 | rs1794867, rs495198, rs2819346, rs2819349, rs10800812, rs10920521, rs6672643, rs2153101, rs2494282, rs4950936, rs946258, rs3820145, rs1340237, rs10128007, rs12079530, rs35068223, rs4550119, rs79707006 | 1q32.1 |
| Chitinase 1 activity | Asthma | 715 | 391 032 | rs495198, rs2486070 | 1q32.1 |
SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; LAVI, left atrial volume index; LVMI, left ventricular mass index; CIMT, carotid intima-media thickness; FeNO, fraction of exhaled nitric oxide; FEV1, forced expiratory volume at 1 s; FVC, forced vital capacity; BRI, bronchial responsiveness index; IgE, immunoglobulin E.