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. 2016 Feb 26;25(10):1934–1945. doi: 10.1093/hmg/ddw066

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Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Brca2^{Δex4–7/Δex4–7};Trp53^Ko/+ mice exhibit increased occurrence of lymphomas, solid tumors and other hematopoietic and proliferative abnormalities. (A) The Kaplan–Meier plot showing tumor-free survival of Brca2^Δex4–7/+, Brca2^{Δex4–7/Δex4–7} and Brca2^Δex4–7/Ko mice (10 males and 10 females/genotype) on a Trp53^+/+ (upper panel; Over all: χ² = 4.226, P = 0.1209) and Brca2^Δex4–7/+;Trp53^Ko/+ and Brca2^{Δex4–7/Δex4–7};Trp53^Ko/+ (lower panel; over all: χ² = 1.730, P = 0.4210). (B) Incidence of hematopoietic neoplasm (Brca2^Δex4–7/+ versus Brca2^Δex4–7/Ko, P = 0.7206; Brca2^Δex4–7/+;Trp53^Ko/+ versus Brca2^{Δex4–7/Δex4–7};Trp53^Ko/+, P = 0.0789), (C) Sarcoma and solid tumor (Brca2^Δex4–7/+;Trp53^Ko/+ versus Brca2^{Δex4–7/Δex4–7};Trp53^Ko/+, P = 0.1050 for solid tumor). N = confirmed pathology per genotype.