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. 2016 Feb 26;25(10):1934–1945. doi: 10.1093/hmg/ddw066

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Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — Aberrant activation of PLK1 following IR in BRCA2^Δex4–7 expressing mES cells. (A) FACS analysis of phospho-histone H3 (Ser10) stained mES cells expressing WT, BRCA2^Δex4–7 and BRCA2^S193A with or without PLK1 inhibitor treatment, following IR. (B) Western blot analysis of total cell lysate from mES cells expressing WT, BRCA2^Δex4–7 and BRCA2^S193A showing total PLK1, activated PLK1-Thr210 and CDK1-Tyr15 levels at different time following release from nocodazole. (C) Densitometric analysis of protein bands shown in (B), normalized against glyceraldehyde-3-phosphate dehydrogenase. The scheme of experimental design is shown at the top of each panel.