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. 2016 Mar 8;25(10):1979–1989. doi: 10.1093/hmg/ddw073

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Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — ASC-JM17 rescues mutant AR toxicity in Drosophila. (A) Eye phenotypes of adult GMR:UAS-AR52^II flies following treatment with vehicle, DHT or DHT and ASC-JM17. (B) Viability of Elav > AR52Q flies reared in the presence or absence of DHT and ASC-JM17 was scored over the course of 10 days. **P < 0.01 (χ² test). (C) Effect of CncC overexpression or knockdown on the DHT-dependent eye phenotype in GMR:UAS-AR52^II flies. (D) Effect of HSF overexpression or knockdown in GMR:UAS-AR52^II flies. Two independent HSF RNAi lines were evaluated.