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. 2016 Mar 8;25(10):1979–1989. doi: 10.1093/hmg/ddw073

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Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 7. — ASC-JM17 increases the expression of Nrf1 and Nrf2 target genes in AR97Q mice. (A and B) Gene expression analysis of Nrf1 (A) and Nrf2 (B) targets in AR97Q mice and non-transgenic littermates (n = 4 per group). Total RNA was extracted from quadriceps muscle of 16-week-old mice. All transcript levels were normalized to Gusb. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01 (Student's t-test). (C and D) Gene expression analysis of Nrf1 (C) and Nrf2 (D) and downstream targets in AR97Q mice treated with ASC-JM17 or vehicle for 6 weeks.