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GBT440 inhibits in vitro sickling of sickle cell trait (SCT) red blood cells (RBCs) under conditions mimicking a combination of hypoxia, dehydration and acidosis. A) Oxygen equilibrium curves (OECs) of SCT blood treated with varying concentrations of GBT440 in hypertonic phosphate buffer, pH 6.9. B) Percentage of sickled SCT RBCs at the indicated oxygen tensions corresponding to the OECs in (A). Mean and standard error of mean shown for n=3 SCT donors.
