Table 2.

Key synthetic Hh pathway inhibitors that function via Smo.

Compound	IC50 Wild-Type Smo	IC50 D473H Smo	References
NVP-LEQ506	1.0 nM	96.0 nM	[37]
ALLO-1	410 nM	1 μM	[38]
ALLO-2	41 nM	83 nM	[38]
IHR-1	0.01 μM	ND	[39]
IHR-NAc	0.0031 μM	ND	[39]
MRT-92	0.7 ± 0.1 nM	0.7 ± 0.2 nM	[42]
MK-5710	17 nM	ND	[41]
16	4 nM	ND	[46]
MS-0022	100 nM	ND	[49]
ITZ	270–690 nMa	500 nM	[50–53]
27	1.3 nM	ND	[60]
30	1.3 nM	ND	[61]
32	0.83 nM	ND	[62]
35	40 nM	ND	[63]
36	19 nM	ND	[64]
NL-103	19.7 nM	Activeb	[65, 66]
38	87 nM	ND	[68]
40	80 nM	ND	[68]
41	58 nM	ND	[68]
22-NHC	3 μM	ND	[72]

ND = Not determined or not reported.

^aDependent on cellular assay.

^bSpecific IC₅₀ values were not reported.