Table 3.

Key Hh pathway inhibitors that affect signaling upstream or downstream of Smo.

Compound	Target	IC₅₀ Wild-Type Smo	IC₅₀ D473H Smo	References
Robotnikin	SHh			[82]
BRD6851	SHh			[83]
GANT58	Gli	5 μM	ND	[86]
GANT61	Gli	5 μM	ND	[86]
ML 340	Gli	34 nM	ND	[94]
FN1-8	Gli	Active^a	ND	[95]
39	Gli	0.5–1.4 μM	ND	[96]
NMDA298-1	Gli	6.9 μM	ND	[97]
JQ1	BRD4	50–150 nM	Active^a	[101]
I-BET151	BRD4	31 nM	ND	[102]

ND = not determined or not reported.

Specific IC₅₀ values were not reported.