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. Author manuscript; available in PMC: 2016 Oct 13.
Published in final edited form as: Curr Med Chem. 2015;22(35):4033–4057. doi: 10.2174/0929867322666150827093904

Table 4.

Small molecules that inhibit Hh signaling through indirect or unknown mechanisms.

Compound Target IC50 Wild-Type Smo IC50 D473H Smo References
Mebendazole Tubulin 0.5 μM Activea [103]
Ciliobrevin A Cytoplasmic Dynein 7 μM ND [105]
Ciliobrevin D Cytoplasmic Dynein 7 μM ND [105]
Eggmanone Phosphodiesterase 4 72 nM ND [106]
Pyrvinium Casein Kinase 1α ~10 nM Activea [110]
Imiquimod Adenosine Receptor Activea ND [114]
CMAP 7 GPR39 20 nM ND [115]
a

Active = Specific IC50 values were not reported.

ND = not determined or not reported.