Figure 3.

Relation between glucose concentration in plasma and CMR_glc in baseline condition. The purple and green solid lines correspond to the mean glucose concentration in the tissue (input) as a function of arterial glucose concentration according to relations (13) and (14), based on experimental studies by Dienel et al. (1991) and Gruetter et al. (1998), respectively. The blue dotted-dashed line corresponds to predictions obtained using parameter set S_R: v_{max_t} = 136 μmol/100 mL/min and K_T = 150 μmol/100 mL_brain. The red dotted-dashed line corresponds to parameter set S_H: v_{max_t} = 68 μmol/100 mL/min and K_T = 50 μmol/100 mL_brain. The gray area corresponds to conditions of normoglycemia in humans (plasma glucose concentration ranging from 400 to 600 μmol/100 mL).