Table 2.
Demographic data, clinical features, and blood biochemistry of 218 patients with acute hepatitis A
| Data on admission | Total (N = 218) | Genotype | ||
|---|---|---|---|---|
| IA | IIIA | |||
| (N = 116) | (N = 48) | P value | ||
| Demographic data | Mean ± SD | |||
| Age (years) | 22.9 ± 4.3 | 22.1 ± 3.5 | 23.7 ± 4.2 | 0.090 |
| Interval from onset to admission (days) | 7.8 ± 5.4 | 7.4 ± 4.8 | 7.8 ± 5.2 | 0.155 |
| Mean duration of hospital stay (days) | 1.9 ± 1.3 | 1.7 ± 1.5 | 2.2 ± 1.4 | 0.588 |
| Clinical features | n (%) | |||
| Dark urine | 214 (98.2) | 112 (96.6) | 48 (100) | 0.193 |
| Anorexia | 210 (96.3) | 113 (97.4) | 48 (100) | 0.261 |
| Malaise | 202 (92.7) | 111 (95.7) | 46 (95.8) | 0.967 |
| Nausea | 193 (88.5) | 104 (89.7) | 44 (91.7) | 0.693 |
| Fever | 191 (87.6) | 103 (88.8) | 42 (87.5) | 0.814 |
| Upper abdominal discomfort | 179 (82.1) | 91 (78.4) | 44 (91.7) | 0.044* |
| Headache | 166 (76.1) | 87 (75.0) | 39 (81.3) | 0.388 |
| Vomiting | 140 (64.2) | 75 (64.7) | 30 (62.5) | 0.794 |
| Arthralgia | 121 (55.5) | ND | ND | ND |
| Pruritus | 107 (49.1) | 56 (48.3) | 23 (47.9) | 0.967 |
| Pale stools | 88 (40.4) | 37 (31.9) | 24 (50.0) | 0.029* |
| Diarrhea | 51 (23.4) | 25 (21.6) | 13 (27.1) | 0.445 |
| Icterus | 216 (99.1) | 114 (98.3) | 48 (100) | 0.360 |
| Cervical lymphadenopathy | 13 (6.0) | 8 (6.9) | 3 (6.3) | 0.880 |
| Hepatomegaly | 159 (72.9) | 79 (68.1) | 36 (75.0) | 0.380 |
| Splenomegaly | 39 (17.9) | 17 (14.7) | 12 (25.0) | 0.114 |
| Blood biochemistry | Mean ± SD | |||
| Total bilirubin (mg/dL) | 6.6 ± 3.6 | 6.57 ± 3.7 | 6.14 ± 3.2 | 0.172 |
| ALT (IU/L) | 507 ± 445 | 566.8 ± 483.3 | 489.1 ± 421.1 | 0.099 |
| ALP (IU/L) | 291 ± 125 | 265 ± 116 | 302.2 ± 147.6 | 0.470 |
| Hemoglobin (g/dL) | 13.3 ± 1.3 | ND | ND | ND |
| WBC (103/mm3) | 6.794 ± 1.563 | 6.517 ± 1.272 | 6.967 ± 1.738 | 0.145 |
| Platelet count (103/mm3) | 239 ± 61 | 241 ± 50.8 | 240.7 ± 93.8 | 0.135 |
ALP = alkaline phosphatase; ALT = alanine aminotransferase; ND = not determined; WBC = white blood cell.