Table 2.
Genotype and allele distributions of TGF-β1 polymorphisms in NPC cases and controls. Odd Ratios obtained by univariate and multivariate analyses
| Polymorphism | Cases n (%) | Controls n (%) | OR (CI 95 %)a | P-value | OR (CI 95 %)b | P-value |
|---|---|---|---|---|---|---|
| TGF-β1 −509 | ||||||
| Genotype | ||||||
| CC | 127 (39.20) | 120 (37.03) | 1.00 | - | 1.00 | - |
| CT | 153 (47.22) | 148 (45.68) | 0.97 (0.69–1.36) | 0.891 | 0.97 (0.69–1.37) | 0.879 |
| TT | 44 (13.58) | 56 (17.29) | 0.74 (0.46–1.18) | 0.211 | 0.73 (0.45–1.17) | 0.194 |
| Allele | ||||||
| C | 407 (62.47) | 388 (59.87) | 1.00 | - | 1.00 | - |
| T | 241 (37.53) | 260 (40.12) | 0.88 (0.70–1.10) | 0.278 | 0.87 (0.70–1.10) | 0.251 |
| TGF–β1 869 | ||||||
| Genotype | ||||||
| TT | 132 (36.57) | 119 (35.52) | 1.00 | - | 1.00 | - |
| TC | 165 (45.70) | 149 (44.48) | 0.99 (0.71–1.39) | 0.992 | 0.99 (0.71–1.38) | 0.955 |
| CC | 64 (17.72) | 67 (20.00) | 0.86 (0.56–1.31) | 0.488 | 0.80 (0.52–1.23) | 0.312 |
| Allele | ||||||
| T | 429 (59.91) | 387 (57.76) | 1.00 | - | 1.00 | - |
| C | 293 (40.09) | 283 (42.23) | 0.93 (0.75–1.15) | 0.530 | 0.92 (0.75–1.14) | 0.453 |
n number of subjects
aUnadjusted Odds ratios and confidence interval for case-control comparison
bOdds ratios and confidence interval adjusted on age, sex and country