Table 4.
Distribution of TGF-β1 polymorphisms genotypes according to age and sex in NPC cases and controls
| ≤30 | >30 | |||||||
|---|---|---|---|---|---|---|---|---|
| Genotype | Cases n (%) | Controls n (%) | OR (CI 95 %)a | P-value | Cases n (%) | Controls n (%) | OR (CI 95 %)a | P-value |
| TGF-β1 −509 | ||||||||
| CC | 26 (30.23) | 30 (38.96) | 1.00 | - | 101 (42.44) | 90 (36.44) | 1.00 | - |
| CT | 42 (48.84) | 31 (40.26) | 1.56 (0.77–3.15) | 0.211 | 111 (46.64) | 117 (47.37) | 0.85 (0.58–1.24) | 0.392 |
| TT | 18 (20.93) | 16 (20.78) | 1.30 (0.55–3.05) | 0.549 | 26 (10.92) | 40 (16.19) | 0.58 (0.32–1.02) | 0.060 |
| TGF-β1 869 | ||||||||
| TT | 32 (34.04) | 23 (29.49) | 1.00 | - | 100 (37.45) | 96 (37.35) | 1.00 | - |
| CT | 44 (46.81) | 42 (53.85) | 0.75 (0.38–1.49) | 0.415 | 121 (45.32) | 107 (41.63) | 1.09 (0.74–1.59) | 0.674 |
| CC | 18 (19.15) | 13 (16.67) | 0.99 (0.41–2.43) | 0.992 | 46 (17.23) | 54 (21.01) | 0.82 (0.50–1.32) | 0.414 |
| Men | Women | |||||||
| Genotype | Cases n (%) | Controls n (%) | OR (CI 95 %)a | P-value | Cases n (%) | Controls n (%) | OR (CI 95 %)a | P-value |
| TGF-β1 −509 | ||||||||
| CC | 88 (40. 00) | 82 (37.27) | 1.00 | - | 39 (37.50) | 38 (36.54) | 1.00 | - |
| CT | 100 (45.45) | 95 (43.18) | 0.98 (0.65–1.48) | 0.927 | 53 (50.96) | 53 (50.96) | 0.97 (0.54–1.75) | 0.931 |
| TT | 32 (14.55) | 43 (19.55) | 0.69 (0.40–1.20) | 0.190 | 12 (11.54) | 13 (12.50) | 0.90 (0.36–2.22) | 0.818 |
| TGF-β1 869 | ||||||||
| TT | 90 (36.00) | 80 (36.20) | 1.00 | - | 42 (37.84) | 39 (34.21) | 1.00 | - |
| CT | 105 (42.00) | 94 (42.53) | 0.99 (0.66–1.50) | 0.973 | 60 (54.05) | 55 (48.25) | 1.01 (0.57–1.80) | 0.965 |
| CC | 55 (22.00) | 47 (21.27) | 1.04 (0.63–1.70) | 0.875 | 9 (8.11) | 20 (17.54) | 0.42 (0.17–1.03) | 0.057 |
n number of subjects
aUnadjusted Odds ratios and confidence interval for case-control comparison