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. 2016 Oct 12;11:51. doi: 10.1186/s13062-016-0154-1

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Examples for the clonal architecture detected in leukemic patients and simulations. Each tree corresponds to one patient. a Clonal hierarchies detected in patients from [12] and in simulations. b Clonal hierarchies detected in simulations but not in patients from [12]. c Clonal hierarchies detected in patients from [12] but not in simulations. The reconstruction of the clonal architecture from genetic measurements is not always unique. In case of ambiguity only one possibility is shown in the figure. Parameters were set as specified in the caption of Fig. 6