Table 4.
Appraisal of the evidence
| Phenotypes | ||||||
|---|---|---|---|---|---|---|
| Author/year | Chronic pain | Inflammatory | Metabolic syndrome | Metabolic bone/cartilage | Mechanical overload | Minimal joint disease |
| Attur 2011 [18] | ++ | |||||
| Bae 2010 [19] | ++ | |||||
| Berry 2010a [20] | ++ | |||||
| Berry 2010b [21] | ++ | |||||
| Blumnenfeld 2013 [22] | ++ | |||||
| Cruz-Almeida 2013 [23] | ++ | |||||
| Doss 2007 [24] | ++ | |||||
| Egsgaard 2015 [25] | + | |||||
| Fernández-Tajes 2014 [26] | ++ | |||||
| Holla 2013 [27] | ++ | |||||
| Jenkins 2015 [28] | + | |||||
| Kerkhof 2008 [29] | ||||||
| Kinds 2013 [9] | ++ | |||||
| King 2013 [30] | + | |||||
| Knoop 2011 [7] | ++ | ++ | ++ | ++ | ||
| Murphy 2011 [31] | ++ | |||||
| Otterness 2000 [32] | ++ | ++ | ||||
| Pereira 2013 [33] | ++ | |||||
| Roemer 2012 [34] | ++ | |||||
| Sowers 2002 [35] | ++ | |||||
| Van der Esch 2015 [36] | ++ | ++ | ++ | ++ | ||
| Van Spil 2012 [37] | ++ | ++ | ||||
| Waarsing 2015 [8] | ++ | ++ | ++ | |||
| Iijima 2015 [38] | + | |||||
| Kittelson 2015 [40] | ++ | |||||
| Total number of studies | 6 (2) | 5 | 4 | 5 | 4 (1) | 6 (1) |
+ high risk of bias, ++ low risk of bias
Total Number of Studies: low risk of bias (high risk of bias)