Table 3.

Differences in transcript levels in colorectal mucosa between poor and good responders to 5-FU-based chemotherapy. Transcript levels of 5-FU pathway genes were compared in mucosas of patients in the testing set divided into groups of poor responders (n = 13) and good responders (n = 13) to the first line chemotherapy regimens based on 5-FU

Gene	Expression level in poor responders vs. good responders
	Fold differenceb	Standard errorb	P-valuea
DPYD	0.76	0.31–1.69	0.259
DPYS	0.91	0.10–6.89	0.434
PPAT	0.88	0.20–3.63	0.086
RRM2	0.31	0.11–1.46	0.038
RRM1	0.59	0.22–1.18	0.014
SLC29A1	0.76	0.17–2.73	0.369
TK1	0.87	0.18–3.66	0.157
TYMP	0.56	0.12–2.46	0.130
TYMS	0.82	0.15–3.77	0.121
UCK1	0.85	0.23–1.96	0.369
UCK2	0.74	0.17–2.42	0.681
UMPS	0.68	0.23–1.21	0.024
UPB1	0.91	0.26–2.85	0.479
UPP1	0.61	0.16–2.10	0.106

Footnotes:

^aAnalyzed by the Mann-Whitney test

^bFold changes and standard error calculated by the REST2009 program

Significant results in bold