Fig. 1.

The global methylation levels and identification of differentially methylated regions (DMRs) in CLL patient samples. a, b Analysis pipeline used to find CLL-associated differentially methylated regions (DMRs). c Differentially methylated regions (DMRs, hypermethylated and hypomethylated) in IGHV-mutated and IGHV-unmutated samples over sorted B cells and normal PBMC. The enrichments shown in the heatmap were within a ±3 kb window from differentially methylated region (DMRs). d The bar graph shows the overall percentage of genome covered by in normal and prognostic CLL groups. e The bar graphs in (e) show the difference in distribution of hypermethylated and hypomethylated patterns across the genome. The peaks used for assigning the genomic regions were derived from MACS with a significance of p < 1E−05