REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit Polyclonal anti-Phospho-Ribosomal protein S6 pSer244/pSer247	Invitrogen	Cat# 44-923G RRID:AB_2533798
Mouse monoclonal anti-GFP	Memorial-Sloan Kettering Monoclonal Antibody Facility	Htz-GFP-19F7 Htz-GFP-19C8
Chicken polyclonal anti-GFP	Abcam	Cat# ab13970 RRID:AB_300798
Rat monoclonal anti-RFP	Chromotek	Cat# rfp-antibody- 5f8 RRID:AB_2336064
Mouse monoclonal anti-galactosidase Beta	Promega	Cat# Z378A RRID:AB_2313752
Mouse monoclonal anti-NeuN	Millipore	Millipore Cat# MAB377, RRID:AB_2298772
Chemicals, Peptides, and Recombinant Proteins
Icilin	Sigma-Aldrich	Cat# I9532; CAS: 36945-98-9
Capsaicin	Calbiochem EMD Millipore	Cat# 211275; CAS: 404-86-4
Clozapine-N-oxide	Tocris Bioscience	Cat# 4936; CAS: 34233-69-7
Critical Commercial Assays
Ovation RNA-Seq System V2	Nugen	Cat#7102-08
Ovation Ultralow DR Multiplex system	Nugen	Cat#0330
RNAscope Manual Fluorescent Multiplex kit	Advanced Cell Diagnostics	Cat#320293/320513
Deposited Data
PhosphoTRAP RNA-Seq raw and analysed data	This paper	GEO: GSE80121
TRAP-Seq RNA-Seq raw and analysed data	This paper	GEO: GSE80120
Experimental Models: Cell Lines
Experimental Models: Organisms/Strains
Mouse: PACAP-2A-Cre/Adcyap1-2A-Cre	Allen Institute for Brain Science	NA
Mouse: BDNF-2A-Cre	This paper	NA
Mouse: Gal-Cre: B6.FVB(Cg)-Tg(Gal- cre)K187Gsat/Mmucd	Mutant Mouse Resource and Research Centers	031060-UCD
Mouse: Vglut2-IRES-Cre: Slc17a6tm2(cre)Lowl	The Jackson Laboratory	016963
Mouse: Gad2-2A-nls-mcherry: B6;129S-Gad2tm1.1Ksvo/J	The Jackson Laboratory	023140
Mouse: Nos1-IRES-Cre: B6.129-Nos1tm1(cre)Mgmj/J	The Jackson Laboratory	017526
Mouse: BDNF-LSL-LacZ: B6.129S2(Cg)-Bdnftm1Krj/J	The Jackson Laboratory	021055
Mouse: Rosa26-LSL-GFPL10a: B6.129S4- Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J	The Jackson Laboratory	022367
Recombinant DNA
AAV2- EF1a-DIO-EGFP-L10a	This Paper (packaged by UNC vector core)	NA
AAV1-CAG-DIO-GCAMP6s	Upenn Vector Core	NA
AAV5- hEF1α -DIO-hChR2(C128S/D156A)-eYFP [SSFO]	UNC Chapel Hill Vector Core	NA
AAV5- EF1a- DIO-hChR2(H134R)-eYFP	UNC Chapel Hill Vector Core	NA
AAV9-hEF1α- DIO-Synaptophysin-mCherry	MIT McGovern Viral Core Facility	NA
HSV-hEF1α-LSL-HAFlagL10a-WPRE-SV40	This paper (packaged by MIT McGovern Viral Core)	NA
AAV2-EF1a-DIO-hM3Dq-mcherry	UNC Chapel Hill Vector Core	NA
Sequence-Based Reagents
EGFP In-situ hybridisation probe	Advanced Cell Diagnostics	400281-C3
mm-BDNF In-situ hybridisation probe	Advanced Cell Diagnostics	424821
BDNF sgRNA sequence: CCATTAAAAGGGGAAGATAGGTTTAAGAGCTATGCT GGAAACAGCATAGCAAGTTTAAATAAGGCTAGTCCG TTATCAACTTGAAAAAGTGGCACCGAGTCGGTGCTT TTTTT	This Paper	NA
BDNF-2A-Cre genotyping primers: Fwd: TCAATACCGGAGATCATGCAAGC Rev: CTGCTGCCATGCATAAAACATT	This Paper	NA
Software and Algorithms
ArrayStar® Version 11.0	DNASTAR Inc.	NA
pClamp 10.5	Molecular Devices	NA
GraphPad Prism 7.0	GraphPad	NA
Other