Skip to main content
. 2016 Aug 12;44(18):8556–8575. doi: 10.1093/nar/gkw723

Figure 1.

Figure 1.

Domain structure of the mammalian DNMT enzymes. The human DNMT1, DNMT3A, DNMT3B and DNMT3L proteins consist of 1616, 912, 853 and 387 amino acid residues, respectively. Abbreviations used: DMAPD – DNA methyltransferase associated protein 1 interacting domain, PBD – PCNA binding domain, NLS – Nuclear localization signal, RFTD – Replication foci targeting domain, CXXC – CXXC domain, BAH1 and BAH2 – bromo-adjacent homology domains 1 and 2, GKn – glycine lysine repeats, PWWP – PWWP domain, ADD – ATRX-DNMT3-DNMT3L domain.