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Structures of DNMT1 with different N-terminal domains. The RFT, CXXC, BAH1, BAH2 and catalytic domains are shown in dark green, red, orange, purple and blue, respectively. (A) DNMT1 in an active conformation with DNA (light green) bound in the active site (29). Removal of the autoinhibitory RFTD can be triggered by UHRF1 (40,41). (B) DNMT1 with unmethylated DNA bound to the autoinhibitory CXXC domain (43). (C) DNMT1 with the RFT domain blocking access to the active site (46).
