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. 2016 Aug 12;44(18):8556–8575. doi: 10.1093/nar/gkw723

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Multimerization of DNMT3A and DNMT3A/DNMT3L complexes. (A) Structure of the DNMT3A–DNMT3L complex with bound DNA. (B) Schematic model of multimerization of the DNMT3A/DNMT3L complexes on DNA. (C) Magnification of a part of B showing the access of active centers of the central DNMT3A subunits to both DNA strands of CpG sites (yellow boxes). (D) Schematic model of DNMT3A protein multimerization and binding to several DNA molecules. (E) Combination of both multimerization processes leading to the 2D multimerization of DNMT3A.