Figure 7.

Model highlighting the co-translational capture of selected nascent chain by Tma108. This study has revealed that Tma108, a putative M1 metallopeptidase, interacts with a subset of ribosomal particles translating mRNA encoding proteins with ATP-binding, RNA-binding and Zinc-binding domains (right). We propose that Tma108 is recruited on selected nascent-chain through interactions involving specific residues located in its catalytic pocket (left). The observation that Tma108 is essential in some cellular contexts (39) strongly suggests that Tma108 could be involved in specific co-translational events.