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. 2016 Oct;46:79–86. doi: 10.1016/j.placenta.2016.08.076

Table 3.

Maternal caruncular and fetal cotyledonary mRNA expression of angiogenic ligands/receptors and glucose transporters in late gestation placentomes.

Placental compartment and gene of interest Control (n = 12) Non-FGR (n = 10) FGR (n = 17) P value
Maternal caruncle VEGFA 27.3 ± 3.04a 23.6 ± 7.45ab 18.3 ± 1.49b 0.014
FLT1 18.8 ± 2.26a 17.3 ± 5.46a 9.6 ± 1.13b 0.002
KDR 23.8 ± 2.40a 21.3 ± 6.72a 15.1 ± 1.40b 0.009
NOS3 28.6 ± 2.82 39.6 ± 12.52 29.9 ± 2.87 0.085
FGF2 15.7 ± 1.54 14.3 ± 4.51 11.5 ± 1.27 0.154
ANGPT1 24.0 ± 1.62a 25.2 ± 7.96a 17.1 ± 1.44b 0.004
ANGPT2 14.0 ± 1.17a 14.9 ± 4.72a 10.9 ± 0.70b 0.010
TEK 21.6 ± 2.63 20.2 ± 6.40 19.6 ± 1.76 0.785
GUCY1 16.5 ± 1.52 13.3 ± 4.20 13.8 ± 1.34 0.276
SLC2A1 18.6 ± 1.14a 19.0 ± 2.05a 13.3 ± 0.84b 0.003
SLC2A3 13.2 ± 0.81a 10.4 ± 0.89b 9.3 ± 0.68b 0.003
Fetal cotyledon VEGFA 26.5 ± 3.53 24.3 ± 7.69 34.7 ± 3.06 0.082
FLT1 15.1 ± 2.42 11.0 ± 3.48 16.7 ± 1.77 0.177
KDR 17.0 ± 2.44 13.5 ± 4.26 21.4 ± 2.12 0.096
NOS3 16.1 ± 2.17 15.4 ± 4.87 22.1 ± 2.56 0.075
FGF2 9.9 ± 1.07 11.6 ± 3.65 11.2 ± 0.86 0.510
ANGPT1 21.9 ± 1.64 23.9 ± 7.56 22.7 ± 0.90 0.654
ANGPT2 13.0 ± 0.79a 18.2 ± 5.76b 16.2 ± 0.92b 0.008
TEK 14.0 ± 0.79 15.5 ± 4.91 16.6 ± 0.73 0.101
GUCY1 8.9 ± 0.90 8.1 ± 2.56 8.5 ± 0.45 0.735
SLC2A1 22.9 ± 1.68 25.1 ± 1.57 23.7 ± 1.00 0.568
SLC2A3 20.7 ± 1.31 20.8 ± 1.00 21.6 ± 0.92 0.800

P values shown are for overall ANOVA – bold indicates p < 0.05. Mean values within a row with unlike superscripts are significantly different (p < 0.05 for individual post-hoc comparisons). Data are presented as mean ± SEM. Abbreviations: VEGFA = vascular endothelial growth factor; FLT1 = fms-related tyrosine kinase 1 (VEGF receptor 1), KDR = kinase insert domain receptor (VEGF receptor 2); NOS3 = nitric oxide synthase 3; FGF2 = fibroblast growth factor 2; ANGPT1 = angiopoietin 1; ANGPT2 = angiopoietin 2; TEK = endothelial tyrosine kinase; GUCY1 = soluble guanylate cyclase (nitric oxide receptor); SLC2A1 = solute carrier family 2 (facilitated glucose transporter) member 1; SLC2A3 = solute carrier family 2 (facilitated glucose transporter) member 3. All data presented are expressed relative to the housekeeping gene 18S.