Table 3.
Placental compartment and gene of interest | Control (n = 12) | Non-FGR (n = 10) | FGR (n = 17) | P value | |
---|---|---|---|---|---|
Maternal caruncle | VEGFA | 27.3 ± 3.04a | 23.6 ± 7.45ab | 18.3 ± 1.49b | 0.014 |
FLT1 | 18.8 ± 2.26a | 17.3 ± 5.46a | 9.6 ± 1.13b | 0.002 | |
KDR | 23.8 ± 2.40a | 21.3 ± 6.72a | 15.1 ± 1.40b | 0.009 | |
NOS3 | 28.6 ± 2.82 | 39.6 ± 12.52 | 29.9 ± 2.87 | 0.085 | |
FGF2 | 15.7 ± 1.54 | 14.3 ± 4.51 | 11.5 ± 1.27 | 0.154 | |
ANGPT1 | 24.0 ± 1.62a | 25.2 ± 7.96a | 17.1 ± 1.44b | 0.004 | |
ANGPT2 | 14.0 ± 1.17a | 14.9 ± 4.72a | 10.9 ± 0.70b | 0.010 | |
TEK | 21.6 ± 2.63 | 20.2 ± 6.40 | 19.6 ± 1.76 | 0.785 | |
GUCY1 | 16.5 ± 1.52 | 13.3 ± 4.20 | 13.8 ± 1.34 | 0.276 | |
SLC2A1 | 18.6 ± 1.14a | 19.0 ± 2.05a | 13.3 ± 0.84b | 0.003 | |
SLC2A3 | 13.2 ± 0.81a | 10.4 ± 0.89b | 9.3 ± 0.68b | 0.003 | |
Fetal cotyledon | VEGFA | 26.5 ± 3.53 | 24.3 ± 7.69 | 34.7 ± 3.06 | 0.082 |
FLT1 | 15.1 ± 2.42 | 11.0 ± 3.48 | 16.7 ± 1.77 | 0.177 | |
KDR | 17.0 ± 2.44 | 13.5 ± 4.26 | 21.4 ± 2.12 | 0.096 | |
NOS3 | 16.1 ± 2.17 | 15.4 ± 4.87 | 22.1 ± 2.56 | 0.075 | |
FGF2 | 9.9 ± 1.07 | 11.6 ± 3.65 | 11.2 ± 0.86 | 0.510 | |
ANGPT1 | 21.9 ± 1.64 | 23.9 ± 7.56 | 22.7 ± 0.90 | 0.654 | |
ANGPT2 | 13.0 ± 0.79a | 18.2 ± 5.76b | 16.2 ± 0.92b | 0.008 | |
TEK | 14.0 ± 0.79 | 15.5 ± 4.91 | 16.6 ± 0.73 | 0.101 | |
GUCY1 | 8.9 ± 0.90 | 8.1 ± 2.56 | 8.5 ± 0.45 | 0.735 | |
SLC2A1 | 22.9 ± 1.68 | 25.1 ± 1.57 | 23.7 ± 1.00 | 0.568 | |
SLC2A3 | 20.7 ± 1.31 | 20.8 ± 1.00 | 21.6 ± 0.92 | 0.800 |
P values shown are for overall ANOVA – bold indicates p < 0.05. Mean values within a row with unlike superscripts are significantly different (p < 0.05 for individual post-hoc comparisons). Data are presented as mean ± SEM. Abbreviations: VEGFA = vascular endothelial growth factor; FLT1 = fms-related tyrosine kinase 1 (VEGF receptor 1), KDR = kinase insert domain receptor (VEGF receptor 2); NOS3 = nitric oxide synthase 3; FGF2 = fibroblast growth factor 2; ANGPT1 = angiopoietin 1; ANGPT2 = angiopoietin 2; TEK = endothelial tyrosine kinase; GUCY1 = soluble guanylate cyclase (nitric oxide receptor); SLC2A1 = solute carrier family 2 (facilitated glucose transporter) member 1; SLC2A3 = solute carrier family 2 (facilitated glucose transporter) member 3. All data presented are expressed relative to the housekeeping gene 18S.