Figure 1.

Index date definition for triple therapy regimen for patients with a treatment gap for either or both of the first 2 agents. If the days supply for all drugs in triple therapy regimen overlapped ≥28 days, the patient qualified as a triple therapy user, and the date that the last drug in the series was prescribed was the index date. If a patient did not have overlap of ≥28 days for all drugs, a patient could qualify as a triple therapy user if a subsequent prescription for either of the first two drugs occurred ≤30 days after the end of the days supply for the first claim for that drug.