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. 2015 Nov 11;60(4):502–512. doi: 10.1111/aas.12652

Figure 1.

Figure 1

Experimental setup. The animals were randomly assigned to one of the four groups: (1) the negative control group without LPS (control group), (2) the positive control group with LPS infusion (LPS group), (3) the albumin‐treated LPS group (ALB+LPS group) to ascertain the protein‐related effects, and (4) the BT086‐treated LPS group (BT086 + LPS group). Following a 30‐min stabilization period (t ‐30), intravenous LPS was administered continuously at a rate of 40 μg/kg/h to all the rabbits, except the animals in the control group. At t0, a standardized amount of Escherichia coli was intravenously injected into all of the animals. After 15 min (t‐15), the control group and the LPS group continuously received a 2 ml/kg/h infusion of balanced electrolyte solution, the ALB + LPS group received 2 ml/kg/h 5% albumin solution, and BT086 + LPS group received 2 ml/kg/h BT086 solution.