Table 1.
Alleviation of obesity and improvement in the levels of blood constituents by quercetin in mice fed a Western diet
Control diet | Western diet | Western diet+ 0.05% quercetin | |
---|---|---|---|
Body weight (g) | 35.66 ± 1.46a | 45.77 ± 0.95b | 41.69 ± 1.33c |
Liver weight (g) | 1.46 ± 0.08a | 3.47 ± 0.28b | 2.13 ± 0.19c |
Kidney weight (g) | 0.37 ± 0.01 | 0.36 ± 0.01 | 0.38 ± 0.01 |
Pancreas weight (g) | 0.28 ± 0.02 | 0.30 ± 0.03 | 0.27 ± 0.02 |
Visceral fat (g/mouse) | 2.25 ± 0.43a | 4.34 ± 0.12b | 3.33 ± 0.36a,b |
Blood glucose (mg/dL) | 143 ± 5a | 224 ± 9b | 151 ± 9a |
Plasma insulin (ng/mL) | 1.84 ± 0.47a | 4.88 ± 0.67b | 2.22 ± 0.32a |
Plasma cholesterol (mg/dL) | 76.2 ± 10.9a | 194.0 ± 9.2b | 123.3 ± 12.4c |
Plasma leptin (ng/mL) | 1.46 ± 0.61a | 5.78 ± 0.58b | 2.81 ± 0.51a |
Plasma adiponectin (μg/mL) | 4.42 ± 0.42a | 2.87 ± 0.11b | 3.18 ± 0.50a,b |
Plasma resistin (ng/mL) | 18.7 ± 1.2 | 22.2 ± 1.4 | 21.8 ± 1.2 |
Plasma TNFα (pg/mL) | 13.2 ± 2.6a | 34.9 ± 3.5b | 19.9 ± 2.8a |
Plasma IFNγ (pg/mL) | 2.11 ± 0.33a | 6.81 ± 1.3b | 3.21 ± 0.58a |
C57BL/6J mice were fed the control AIN93G diet or a Western diet containing either 0% or 0.05% quercetin for 18 weeks. Values are expressed as the mean ± SEM of 6–9 mice in each group. Different superscripts indicate significant differences (p < 0.05, two‐sided).