Table 3.

Upstream regulators predicted to be activated or inhibited by quercetinin EAT in mice fed a Western diet

Prediction
Activated upstream regulator	Inhibited upstream regulator
LEPR (16 target molecules in dataset), NPC1 (5)	IFNγ (57 target molecules in dataset), mir‐223 (18), ABCB6 (7), cholesterol (7), ALOX5 (4) SPI1 (9), SPIB (11)

p values < 0.05 were considered to be a significant dataset of the targets of each upstream regulator (Fisher's exact test). An absolute z‐score below (inhibited) or above (activated) 2 was considered significant.

LEPR, leptin receptor; NPC1, NiemannPick disease, type C; mir‐223, microRNA‐223; ABCB6, ATP‐binding cassette, sub‐family B (MDR/TAP), member 6; ALOX5, arachidonate 5‐lipoxygenase; SPI1, transcription factor PU.1; SPIB, Spi‐B transcription factor (Spi‐1/PU.1 related).