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. 2015 Nov 25;67(12):3104–3112. doi: 10.1002/art.39322

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© 2015 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Predicted response at week 12 and proportion of week 12 predicted responders with low levels of disease activity according to the DAS28‐ESR at week 52 and in remission/low disease activity at week 12 and week 52 (full analysis set; nonresponder imputation). A, Proportion of patients in remission and low disease activity according to the DAS28‐ESR at week 12 and week 52. B, Proportion of week 12 responders and week 12 responders with low disease activity according to the DAS28‐ESR at week 52. The difference in proportions for the RAPID‐3 arm minus the CDAI arm was analyzed using nonparametric analysis of covariance with the assessment tool as the factor and with the baseline DAS28‐ESR, sex, age, prior anti‐TNF use, and duration of RA (<2 or ≥2 years) as covariates. 95% CI = 95% confidence interval (see Figure 1 for other definitions).