Table 1.
Clinicopathological characteristics of 735 patients with head and neck squamous cell carcinoma molecularly profiled.
| Patient characteristic | All HNSCC (n = 735) | HPV‐positive (n = 39) | HPV‐negative (n = 49) |
|---|---|---|---|
| Age, y | |||
| Average (range) | 59.5 (19–90) | 59.2 (40–80) | 57.5 (27–87) |
| Sex (%) | |||
| Male | 570 (78) | 33 (85) | 34 (69) |
| Female | 165 (22) | 6 (15) | 15 (31) |
| Tumor sites in head and neck, no. (%) | |||
| Oropharynx | 372 (51) | 31 (79) | 25 (51) |
| Nasopharynx | 63 (9) | – | 4 (8.2) |
| Pharynx | 40 (5) | 1 (3) | 3 (6.1) |
| Larynx | 80 (11) | 2 (5) | 5 (10.2) |
| Oral cavity | 67 (9) | 1 (3) | 6 (12.25) |
| Head and neck, NOS | 113(15) | 4 (10) | 6 (12.25) |
| Site of tumor profiled, no. (%) | |||
| Primary sites | 321(44) | 19 (49) | 18 (37) |
| Metastatic sites* | 414 (56) | 20 (51) | 31 (63) |
Abbreviations: HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; NOS, not otherwise specified.
*Including: connective and soft tissue of head, face, and neck (n = 138); lymph nodes (n = 93); lung and bronchus (n = 75); liver (n = 34); bones and joints (n = 26); pleura (n = 7); chest and NOS (n = 6); skin (n = 3); colon (n = 5); mediastinum (n = 4); pelvis and NOS (n = 3); retroperitoneum and peritoneum (n = 5); stomach (n = 3); vertebra (n = 5); adrenal gland (n = 3); brain (n = 2); orbit (n = 1); and small bowel (n = 1).