Table 1.

Major genes associated with inherited arrhythmias.

Disease	Genes (yield, %)
Long QT syndrome	KCNQ1 (30–35), KCNH2 (25–30), SCN5A (5–10) [25]
Catecholaminergic Polymorphic Ventricular Tachycardia	RYR2 (60–65),CASQ2 (<5) [47], [49]
Brugada Syndrome	SCN5A (20) [60]
Hypertrophic cardiomyopathy	MYBPC3 (30–40), MYH7 (20–30), TNNT2 (10), TNNI3 (7) [66]
Dilated cardiomyopathy	TTN (~25) [80]
Arrhythmogenic right ventricular dysplasia/cardiomyopathy	PKP2 (46), PLN (5) [62]