Fig. 3.
FKBP12.6 dissociation from mutant RyR2 in the pathogenesis of CPVT [8]. FKBP12.6 acts as a stabilizer that preserves the closed RyR2 channel during diastole. Weakened binding affinity with FKBP12.6 may lead to a Ca2+ leak during diastole.
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