Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Defective intramolecular domain interactions in RyR2 mutations [8]. The N terminal domain and the central domain of RyR2 interact with a tight “zipping” that serves to stabilize the channel (left panel). A mutation in either domain weakens this interaction (unzipping), which results in leaking of Ca2+ from RyR2 (right panel).
