Skip to main content
. 2015 Nov 24;32(5):344–351. doi: 10.1016/j.joa.2015.09.008

Fig. 6.

Fig. 6.

Molecular and functional abnormalities related to mutations in the CASQ2 gene [8]. Storage of Ca2+ in the SR largely depends on the level and function of CASQ2 (upper panel). Decreased levels or function of CASQ2 results in increase in the free SR Ca2+ that may result in a Ca2+ leak from RyR2 during diastole (lower panel).