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. 2016 Oct 13;11(10):e0164727. doi: 10.1371/journal.pone.0164727

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© 2016 O’Sullivan et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Partial reversal of the effect of PDGF 10ng/ml by nilotinib 0.1μM on (A) expression of OPG mRNA in ST2 cells and (E) production of OPG protein by ST2 cells. Reversal of the effect of PDGF 10ng/ml by nilotinib 1.0μM on (B) expression of OPG mRNA in ST2 cells and (F) production of OPG protein by ST2 cells. Partial reversal of the effect of PDGF 10ng/ml by imatinib 0.1μM on (C) expression of OPG mRNA in ST2 cells and (G) production of OPG protein by ST2 cells. Reversal of the effect of PDGF 10ng/ml by imatinib 1.0μM on (D) expression of OPG mRNA in ST2 cells and (H) production of OPG protein by ST2 cells. Gene expression is quantitated relative to the appropriate baseline value. Data are mean ± SEM. ^nsnot significant, *p<0.05, **p<0.01, ***p<0.001 vs PDGF/nilotinib-treated or PDGF/imatinib-treated group. NIL, nilotinib. IM, imatinib.