Fig 7. Mechanisms by Which Inhibition of PDGFRβ by TKIs or Gene Silencing Inhibits Osteoclastogenesis.

TKIs or PDGFRB gene silencing (SiRNA) inhibit PDGFRβ signaling (1) with a resultant increase in OPG production (2). This reduces RANK-RANKL interaction (3) leading to inhibition of osteoclast differentiation (4). Additionally, TKIs reduce RANKL secretion but not through PDGFRβ-mediated mechanisms.