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. 2016 Oct 13;11(10):e0164575. doi: 10.1371/journal.pone.0164575

Fig 5. Spearman correlation network for samples treated with LPS and heat stress samples at time point 2h.

Fig 5

(A) The complete network showing interaction between genes at 0 hours after LPS under heat stress treatment. Highly connected hubs includes CASP9, IL18, IFNB, IL8, and iNOS. There appears to be a small cluster of genes related to apoptotic pathway formed near the top of the network. (B) Cluster 2 from MCODE network clustering algorithm showing the interaction between IL8, IL18, TLR4, TRAF6, CD40, IFNB, IFNG, and CASP9. The cluster shows interaction between multiple mechanisms during response to LPS stimulation under heat stress. Interesting to note once again the additional interaction with the CASP9/CASP3 apoptotic pathway.