Table 3. Association of VDR and GC gene polymorphisms with colorectal cancer risk according to plasma vitamin D concentration.
| Variant | Categories of plasma vitamin D | Pc | ||||
|---|---|---|---|---|---|---|
| Low (< 25.1 ng/mL) | High (≥ 25.1 ng/mL) | |||||
| Na | OR (95% CI)b | Na | OR (95% CI)b | |||
| rs4237856 | AA | 105/213 | 1.00 (ref.) | 108/210 | 1.00 (0.67–1.48) | 0.74 |
| CA+CC | 73/140 | 1.04 (0.71–1.52) | 70/145 | 0.95 (0.62–1.47) | ||
| rs4073729 | GG | 112/228 | 1.00 (ref.) | 106/221 | 0.95 (0.64–1.40) | 0.70 |
| GA+AA | 63/123 | 1.00 (0.67–1.47) | 72/132 | 1.05 (0.68–1.64) | ||
| rs7970314 | AA | 44/93 | 1.00 (ref.) | 48/95 | 0.99 (0.57–1.70) | 0.93 |
| GA+GG | 133/260 | 1.04 (0.68–1.60) | 130/259 | 1.00 (0.62–1.61) | ||
| rs11568820 (Cdx2) | CC | 67/134 | 1.00 (ref.) | 67/136 | 0.92 (0.58–1.47) | 0.78 |
| TC+TT | 110/219 | 0.96 (0.66–1.41) | 111/218 | 0.96 (0.63–1.48) | ||
| rs7299460 | TT | 42/90 | 1.00 (ref.) | 48/93 | 1.05 (0.61–1.82) | 0.70 |
| TC+CC | 136/263 | 1.10 (0.71–1.68) | 130/262 | 1.03 (0.64–1.65) | ||
| rs7136534 | CC | 77/158 | 1.00 (ref.) | 77/157 | 0.96 (0.62–1.50) | 1.00 |
| TC+TT | 101/195 | 1.05 (0.73–1.51) | 101/198 | 1.01 (0.66–1.54) | ||
| rs10875695 | CC | 70/143 | 1.00 (ref.) | 71/142 | 0.98 (0.62–1.54) | 0.91 |
| CA+AA | 108/210 | 1.02 (0.70–1.49) | 107/213 | 0.97 (0.64–1.49) | ||
| rs4334089 | GG | 64/137 | 1.00 (ref.) | 66/136 | 1.00 (0.63–1.59) | 0.84 |
| GA+AA | 114/216 | 1.11 (0.76–1.63) | 112/219 | 1.05 (0.68–1.62) | ||
| rs4760648 | CC | 50/104 | 1.00 (ref.) | 45/99 | 0.88 (0.51–1.53) | 0.73 |
| TC+TT | 128/249 | 1.06 (0.71–1.58) | 133/256 | 1.04 (0.67–1.60) | ||
| rs2853564 | AA | 82/175 | 1.00 (ref.) | 70/163 | 0.87 (0.56–1.35) | 0.47 |
| GA+GG | 96/178 | 1.16 (0.80–1.67) | 108/192 | 1.23 (0.80–1.88) | ||
| rs2238136 | CC | 116/210 | 1.00 (ref.) | 125/231 | 0.97 (0.66–1.42) | 0.90 |
| TC+TT | 62/143 | 0.82 (0.56–1.20) | 53/124 | 0.77 (0.49–1.20) | ||
| rs2254210 | GG | 88/201 | 1.00 (ref.) | 84/185 | 1.01 (0.66–1.55) | 0.83 |
| GA+AA | 89/152 | 1.36 (0.93–1.99) | 94/169 | 1.30 (0.84–2.02) | ||
| rs2228570 (FokI) | GG | 66/138 | 1.00 (ref.) | 65/135 | 0.95 (0.59–1.54) | 0.96 |
| GA+AA | 112/215 | 1.09 (0.75–1.59) | 113/220 | 1.05 (0.69–1.61) | ||
| rs2239186 | AA | 47/94 | 1.00 (ref.) | 57/101 | 1.07 (0.63–1.84) | 0.61 |
| GA+GG | 131/259 | 0.96 (0.64–1.46) | 121/254 | 0.89 (0.56–1.42) | ||
| rs2189480 | TT | 62/153 | 1.00 (ref.) | 58/122 | 1.11 (0.69–1.80) | 0.38 |
| TG+GG | 116/200 | 1.42 (0.97–2.07) | 120/233 | 1.23 (0.81–1.88) | ||
| rs2239179 | TT | 99/214 | 1.00 (ref.) | 95/201 | 0.98 (0.65–1.46) | 0.85 |
| TC+CC | 79/139 | 1.24 (0.86–1.78) | 83/154 | 1.15 (0.76–1.75) | ||
| rs1540339 | TT | 84/197 | 1.00 (ref.) | 88/185 | 1.05 (0.69–1.60) | 0.46 |
| TC+CC | 94/156 | 1.44 (1.00–2.06) | 90/170 | 1.25 (0.82–1.90) | ||
| rs2283342 | GG | 45/109 | 1.00 (ref.) | 52/83 | 1.41 (0.82–2.44) | 0.08 |
| GA+AA | 133/244 | 1.33 (0.88–2.01) | 126/272 | 1.11 (0.70–1.77) | ||
| rs2107301 | AA | 81/188 | 1.00 (ref.) | 84/181 | 1.03 (0.67–1.57) | 0.62 |
| GA+GG | 97/165 | 1.38 (0.97–1.98) | 94/174 | 1.25 (0.82–1.91) | ||
| rs2239182 | TT | 100/216 | 1.00 (ref.) | 93/204 | 0.95 (0.64–1.42) | 0.98 |
| TC+CC | 78/137 | 1.25 (0.87–1.79) | 85/150 | 1.20 (0.79–1.81) | ||
| rs11168267 | GG | 127/243 | 1.00 (ref.) | 136/239 | 1.08 (0.74–1.56) | 0.23 |
| GA+AA | 51/110 | 0.88 (0.59–1.31) | 42/116 | 0.67 (0.42–1.06) | ||
| rs10875692 | CC | 137/273 | 1.00 (ref.) | 137/287 | 0.92 (0.64–1.31) | 0.45 |
| TC+TT | 41/80 | 1.08 (0.70–1.66) | 41/68 | 1.25 (0.77–2.04) | ||
| rs11574113 | CC | 124/228 | 1.00 (ref.) | 134/228 | 1.09 (0.75–1.58) | 0.24 |
| GC+GG | 54/125 | 0.79 (0.54–1.16) | 44/127 | 0.61 (0.39–0.97) | ||
| rs7975232 (ApaI) | CC | 85/177 | 1.00 (ref.) | 98/159 | 1.23 (0.81–1.87) | 0.06 |
| CA+AA | 93/176 | 1.07 (0.74–1.53) | 80/196 | 0.81 (0.53–1.23) | ||
| rs731236 (TaqI) | AA | 131/292 | 1.00 (ref.) | 133/271 | 1.05 (0.74–1.50) | 0.17 |
| GA+GG | 47/61 | 1.69 (1.10–2.60) | 45/84 | 1.16 (0.72–1.87) | ||
| rs3847987 | CC | 124/233 | 1.00 (ref.) | 134/228 | 1.11 (0.76–1.62) | 0.16 |
| CA+AA | 54/120 | 0.84 (0.57–1.25) | 44/127 | 0.63 (0.40–0.99) | ||
| rs11574143 | CC | 127/241 | 1.00 (ref.) | 140/235 | 1.13 (0.78–1.64) | 0.09 |
| TC+TT | 51/112 | 0.87 (0.58–1.29) | 38/120 | 0.60 (0.37–0.95) | ||
| rs7968585 | CC | 87/187 | 1.00 (ref.) | 104/165 | 1.28 (0.85–1.94) | 0.025 |
| TC+TT | 91/166 | 1.14 (0.79–1.64) | 74/190 | 0.81 (0.53–1.24) | ||
| rs12721364 | AA | 57/113 | 1.00 (ref.) | 64/116 | 1.02 (0.62–1.67) | 0.79 |
| GA+GG | 120/240 | 0.99 (0.67–1.47) | 114/238 | 0.93 (0.60–1.45) | ||
| rs4588 | GG | 92/182 | 1.00 (ref.) | 108/222 | 0.95 (0.64–1.42) | 0.89 |
| TG+TT | 86/171 | 1.00 (0.69–1.45) | 70/133 | 0.99 (0.63–1.55) | ||
| rs7041 | AA | 101/212 | 1.00 (ref.) | 96/170 | 1.14 (0.75–1.72) | 0.20 |
| CA+CC | 77/141 | 1.15 (0.79–1.67) | 82/185 | 0.92 (0.61–1.40) | ||
VDR SNPs are ordered by their occurrence in the gene from 5′ to 3′ end.
aNumber of cases/controls.
bOdds ratios (OR) and 95% confidence intervals (CI). Adjusted for age, sex, fasting time, and season of blood sampling (matching factors), and smoking, alcohol use, physical activity, body mass index, and family history of colorectal cancer.
cP values for interaction, unadjusted for multiple comparisons. Interaction P value after multiple comparison adjustment was 1.00 for all models except for one associated with rs7968585, which was 0.38.