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. 2016 Oct 13;11(10):e0164156. doi: 10.1371/journal.pone.0164156

Table 3. HIV pre-treatment drug resistance by year of enrolment.

Year n Any ARV Drug NNRTI PDR NRTI PDR PI PDR NRTI + NNRTI PDR
2011 17 5.9 (0.1, 28.7) 0.0 (0.0, 19.5) 5.9 (0.1, 28.7) 0.0 (0.0, 19.5) 0.0 (0.0, 19.5)
2012 88 18.2 (10.8, 27.8) 8.0 (3.3, 15.7) 6.8 (2.5, 14.3) 4.5 (1.3, 11.2) 1.1 (0.0, 6.2)
2013 69 20.3 (11.6, 31.7) 14.5 (7.2, 25.0) 7.2 (2.4, 16.1) 1.4 (0.0, 7.8) 2.9 (0.4, 10.1)
2014 61 18.0 (9.4, 30.0) 11.5 (4.7, 22.2) 4.9 (1.0, 13.7) 1.6 (0.0, 8.8) 0.0 (0.0, 5.9)
2015 48 27.1 (15.3, 41.8) 16.7 (7.5, 30.2) 8.3 (2.3, 20.0) 4.2 (0.5, 14.3) 2.1 (0.1, 11.1)
p-valuea 0.0536 0.0422 NS NS NS
2011–2015 283 19.4 (15.0, 24.5) 11.3 (7.9, 15.6) 6.7 (4.1, 10.3) 2.8 (1.2, 5.5) 1.4 (0.4, 3.6)

a Linear regression (slope significantly different to zero) for each drug class. HIVDR defined with the HIVdb tool, using Sanger sequences. NS, non-significant (p>0.05).