Table 4. Effects of Line, Exercise, and their interaction on expression of mitochondrial genes.

Human Gene (fly ortholog)	Gene fuction	Line	Treatment	Line * Treatment
MFN1 (fzo)	mitochondrial fusion	<0.01	<0.001	<0.01
MFN2 (Marf)	mitochondrial fusion	ns	<0.01	ns
FIS1 (Fis1)	mitochondrial fission	ns	<0.01	ns
OPA1 (Opa1)	mitochondrial fusion	ns	ns	ns
DNM1L(Drp1)	mitochondrial fission	ns	<0.01	ns
CYTC (Cyt-c-d)	electron transfer protein	<0.01	<0.001	<0.01
ETFDH (Etf-QO)	electron transfer protein	ns	<0.001	ns
ETFB (CG7834)	electron transfer protein	ns	<0.05	ns
TFAM (TFAM)	marker of mitochondrial biogenesis, associated with mitochondrial density	<0.05	<0.01	<0.05
PPARGC1A (srl)	transcriptional co-activator regulating genes involved in OXPHOS	ns	<0.05	ns
VEGFA / PDGFA (Pvf1)	angiogenesis and vasculature	ns	ns	ns
LDB3 (Zasp52)	sarcomere formation	ns	ns	ns
SDC (Sdc)	transmembrane receptor involved in energy homeostasis	ns	ns	ns

ANOVA analysis, Bold indicates significance at a Bonferroni level. ns–not significant Data from Study B.