Table 1. Renal pathology scores in TgFVB and HIV-1 transgenic congenic and sub-congenic strains.
| Phenotype | TgFVB | Congenic | Sub-II | Sub-III | Sub-IV | |
|---|---|---|---|---|---|---|
| CAST/FVB | age (weeks) | 7.3±.2 | 7.1±0.3 | 6.4±0.2 | 7.1±0.2 | 7.2±0.2 |
| sex | 17M/29F | 11M/14F | 9M/15F | 20M/16F | 12M/20F | |
| GS (%) | 26.4±3.6 | 46.7±6.6 | 14.3±3.2 | 38.9±4.4 | 41.6±5.3 | |
| Tub-int/casts (%) | 14.3±2 | 33.56±4.7 | 11.5±2.6 | 23.8±2.6 | 24.4±3 | |
| Tub. Atr. & Fibr(%) | 7.2±1.4 | 13.2±2.2 | 3±1 | 15.4±2.7 | 15±2.7 | |
| Inflam. (%) | 11.4±2.2 | 16.9±2.8 | 5.5±1.9 | 21.7±3.4 | 21.5±3.6 | |
| CAST/CAST | age (weeks) | 7.3±.2 | 6.5±0.2 | 7.4±0.5 | 6.7±0.3 | |
| sex | 17M/29F | - | 5M/8F | 7M/7F | 9M/13F | |
| GS (%) | 26.4±3.6 | - | 21.8±6.3 | 64.1±6.4 | 65±5.6 | |
| Tub-Int/casts (%) | 14.3±2 | - | 16.2±4.6 | 38.5±5.7 | 36±3.7 | |
| Tub. Atr. & Fibr(%) | 7.2±1.4 | - | 6.4±2 | 20.1±4.7 | 19.0±3.1 | |
| Inflam. (%) | 11.4±2.2 | - | 13.2±4.6 | 28.1±5 | 28.3±3.2 |
The histology phenotypes are expressed at percent of affected kidney segments after visualization of at least 200 glomeruli. GS = Percent glomeruli with sclerosis, Tub-Int/casts = Percent tubular interstitial cystic dilation/casts, Tub. Atr.&Fibr = Percent tubular atrophy and fibrosis, Inflam. = Percent of sections containing inflammatory infiltrates. Male (M) and female (F) distribution by group is also indicated. The trait values are shown as mean ± standard error of mean. Statistically significant differences between groups are indicated in Fig 2.